The Butterfly Effect 2 (2006)

After his girlfriend, Julie and two best friends are killed in a tragic auto accident, Nick struggles to cope with his loss and grief. Suffering from migraine-like seizures, Nick soon discovers that he has the power to change the past via his memories. However, his time-traveling attempts to alter the past and save his one true love have unexpected and dire consequences.

• brain tumor
• suicide
• time travel
• underwear